The focus of our research is to obtain an understanding of multi-phase flow phenomena at nano-to-micro scale and use the knowledge to develop integrated, automated and high-throughput microfluidic and Lab-on-a-Chip (LoC) devices for medical, biological, and environmental applications. We are interested in all aspects of these miniaturized devices, including the design of functional materials, development of compatible microfabrication techniques for their integration into LoC devices in the form of microstructures, and application of such devices in organism-on-a-chip assays, point-of-care diagnostics and point-of-need detection of various analytes and biomarkers

FUNCTIONAL MATERIALS AND MICROSTRUCTURES IN MINIATURIZED DEVICES

We aim to develop composite polymers with functional properties (e.g., electrical, thermal, optical) for sensing and actuation purposes and integrate them into miniaturized microfluidic devices in the form of 3D microstructures using novel microfabrication techniques.

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APPLICATIONS OF MINIATURIZED DEVICES

Organisms-on-a-Chip

Studying human diseases and screening for therapeutic and preventive drug leads can be done at high throughput using in-vivo model organisms such as Caenorhabditis elegans, Drosophila melanogaster, and Danio rerio. What is missing is technologies to enhance the speed and precision of these assays for multi-phenotypic investigations. We develop Lab on a Chip and miniaturized microfluidic devices that provide high precision and control for studying model organisms neuronal and behavioral responses to various environmental cues such as mechanical, thermal, electrical and chemical stimuli. Our goal is to develop high throughput chemical screening devices for in-vivo drug discovery applications.

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Sorting and Separation

Physical, chemical, and biological pollutants, contaminants, and pathogens play a critical role in causing waterborne and foodborne diseases with catastrophic medical, social and economic impacts on our lives. We conduct research on microfluidic devices to perform multi-phase fluid sample (e.g. water, beverages, blood) preparation in order to sort, separate and detect harmful molecules, cells, microorganisms and microparticles in a rapid, precise and automated manner. Our goal is to enhance the throughput of such devices and achieve multiplexed detection with high sensitivity and accuracy for applications in environmental safety and Point of Care (POC) diagnosis.

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